Cell division protein FtsZ: from structure and mechanism to antibiotic target
نویسندگان
چکیده
منابع مشابه
Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ.
The worldwide spread of antibiotic-resistant bacteria has lent urgency to the search for antibiotics with new modes of action that are devoid of preexisting cross-resistances. We previously described a unique class of acyldepsipeptides (ADEPs) that exerts prominent antibacterial activity against Gram-positive pathogens including streptococci, enterococci, as well as multidrug-resistant Staphylo...
متن کاملCell division and transcription of ftsZ.
For normal cell division, the ftsZ gene must be transcribed from a number of promoters that are located within the proximal upstream genes (ddlB, ftsQ, and ftsA). We show that the main promoters have identical responses to changes in growth rate, i.e., under all conditions, the frequency of transcription per septum formed is approximately constant and independent of cell size or growth rate per...
متن کاملThe interactions of cell division protein FtsZ with guanine nucleotides.
Prokaryotic cell division protein FtsZ, an assembling GTPase, directs the formation of the septosome between daughter cells. FtsZ is an attractive target for the development of new antibiotics. Assembly dynamics of FtsZ is regulated by the binding, hydrolysis, and exchange of GTP. We have determined the energetics of nucleotide binding to model apoFtsZ from Methanococcus jannaschii and studied ...
متن کاملDirect interaction between the cell division protein FtsZ and the cell differentiation protein SpoIIE.
SpoIIE is a bifunctional protein with two critical roles in the establishment of cell fate in Bacillus subtilis. First, SpoIIE is needed for the normal formation of the asymmetrically positioned septum that forms early in sporulation and separates the mother cell from the prespore compartment. Secondly, SpoIIE is essential for the activation of the first compartment-specific transcription facto...
متن کاملTargeting the Bacterial Division Protein FtsZ.
Similar to its eukaryotic counterpart, the prokaryotic cytoskeleton is essential for the structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central player in the cytoskeletal family, forms a cytokinetic ring at mid-cell, and recruits the division machinery to orchestrate cell division. Cells depleted of or lacking functional FtsZ do not divide and grow into...
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ژورنال
عنوان ژورنال: Future Microbiology
سال: 2020
ISSN: 1746-0913,1746-0921
DOI: 10.2217/fmb-2019-0348